Cytoplasmic Localization of Thyroid Hormone Receptor (TR) Alpha and Nuclear Expression of Its Isoform TRα2 Determine Survival in Breast Cancer in Opposite Ways

The aim of this retrospective study was to assess the respective prognostic values cytoplasmic and nuclear TRα, TRα1, TRα2 expression in breast cancer (BC) tissue samples correlate results with clinico-pathological parameters. In 249 BC patients, patterns general TRα α1 α2 isoforms were evaluated via immuno-histochemistry. Prognosis-determining aspects calculated univariate, as well multivariate, analysis. Univariate Cox-regression analysis revealed no association between overall survival (OS) (p = 0.126), whereas significantly correlated a poor outcome for both OS 0.034) ten-year 0.009). Strengthening these results, found be an independent marker 0.010) when adjusted fit Analyses TRα-subgroups that TRα1 had relevance, positively associated 0.014), 0.029), DFS 0.043). Additionally, positive prognosticator 0.030) Overall, our support hypothesis subcellular localization its plays important role carcinogenesis prognosis cancer. Cytoplasmic correlates more aggressive disease progression, appears protective factor. These data may help us prioritize high-risk subgroups possible targeted tumor therapy.